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WOO Je-Tae


Year of Birth 1961
Place of Birth Korea
Title Professor
Belong to Dept. of Biological Chemistry
Bioscience and Biotechnology (graduate school)
Research Institute for Biological Functions
Creative Liberal Arts Center
Graduated Tokyo University of Agriculture and Technology, Graduate School of Agriculture
Degree Dr. of Agriculture, Tokyo University of Agriculture and Technology
Dr. of Mediclicine, Tokyo Medical University
Academic Institutional Membership Japan Society for Bioscience, Biotechnology, and Agrochemistry, Japanese Association for Animal Cell Technology, American Society for Bone and Mineral Research
Field of Study Bioactive Natural Products and Cellular Biochemistry
Research, Studies Screening, Isolation and Biological Activities of Natural Products
Curriculum Specialized Chemistry of Natural Products, Cellular Biochemistry of Bioactive Compounds, Cell Technology

Books Published, Translation

Dietary flavonoids and their effects on osteoclast differentiation and function. Bromacology: Pharmacology of Foods and Their Components Research Signpost, 35-52., 2008

Cahallenges of nutriproteimics for Bromacology Bromacology: Pharmacology of Foods and Their Components Research Signpost., 171-188., 2008

Academic Papers, Critique

Nam SH, Yamano A, Kim JA, Lim J, Baek SH, Kim JE, Kwon TG, Saito Y, Teruya T, Choi SY, Kim YK, Bae YC, Shin HI, Woo JT, Park EK. Prenylflavonoids isolated from Macaranga tanarius stimulate odontoblast differentiation of human dentalpulp stem cells and tooth root formation via the mitogen-activated proteinkinase and protein kinase B pathways. Int Endod J. 2021 Feb 28. doi:10.1111/iej.13503. Epub ahead of print. PMID: 33641170.

Natsume N, Yamano A, Watanabe A, Yonezawa T, Woo JT, Yamakuni T, Teruya T. Effect of methoxyflavones contained in Kaempferia parviflora on CRE-mediatedtranscription in PC12D cells. Bioorg Med Chem Lett. 2020 Dec 1;30(23):127606.doi: 10.1016/j.bmcl.2020.127606. Epub 2020 Oct 7. PMID: 33038547.

Natsume N, Yonezawa T, Woo JT, Teruya T. Effect of pinocembrin isolated from Alpinia zerumbet on osteoblast differentiation. Cytotechnology. 2020 Oct 7. doi:10.1007/ s10616-020-00427-2. Epub ahead of print. PMID: 33029744.

Tsuboi T, Lu R, Yonezawa T, Watanabe A, Woo JT, Abe-Dohmae S, Yokoyama S. Molecular mechanism for nobiletin to enhance ABCA1/G1 expression in mouse macrophages. Atherosclerosis. 2020 Mar;297:32-39. doi:10.1016/j. atherosclerosis. 2020.01.024. Epub 2020 Feb 6. PMID: 32062137.

Kim YJ, Kim SR, Kim DY, Woo JT, Kwon EY, Han Y, Choi MS, Jung UJ. Supplementation of the Flavonoid Myricitrin Attenuates the Adverse Metabolic Effects of Long-Term Consumption of a High-Fat Diet in Mice. J Med Food. 2019 Nov;22(11):1151-1158. doi: 10.1089/jmf.2018.4341. Epub 2019 Sep 24. PMID: 31549892.

Lee JH, Kim YG, Khadke SK, Yamano A, Woo JT, Lee J. Antimicrobial andantibiofilm activities of prenylated flavanones from Macaranga tanarius. Phytomedicine. 2019 Oct;63:153033. doi: 10.1016/j.phymed.2019.153033. Epub 2019 Jul 13. PMID: 31352284.

Segawa R, Shiraki M, Sudo S, Shigeeda K, Saito T, Mizuno N, Moriya T, Yonezawa T, Woo JT, Hiratsuka M, Hirasawa N. A chalcone derivative suppresses the induction of TSLP in mice and human keratinocytes and attenuates OVA-induced antibody production in mice. Eur J Pharmacol. 2019 May 15;851:52-62. doi: 10.1016/ j.ejphar.2019.02.007. Epub 2019 Feb 10. PMID: 30753864.

Weng Y, Wang J, Yang Z, Xi M, Duan J, Guo C, Yin Y, Segawa R, Moriya T, Yonezawa T, Cha BY, Woo JT, Wen A, Hirasawa N. A steroid alkaloid derivative 02F04 upregulates thymic stromal lymphopoietin expression slowly and continuously through a novel Gq/11-ROCK-ERK1/2 signaling pathway in mouse keratinocytes. Cell Signal. 2019 May;57:58-64. doi: 0.1016/j.cellsig.2019.01.005. Epub 2019 Jan 19. PMID: 30664940.

Mitani Y, Satake K, Tsukamoto M, Nakamura I, Kadioglu O, Teruya T, Yonezawa T, Cha BY, Efferth T, Woo JT, Nakagawa H. Epimagnolin A, a tetrahydrofurofuranoid lignan from Magnolia fargesii, reverses ABCB1-mediated drug resistance. Phytomedicine. 2018 Dec 1;51:112-119. doi: 10.1016/j.phymed.2018.06.030. Epub 2018 Jun 20. PMID: 30466608.

Fujiwara N, Lee JW, Kumakami-Sakano M, Otsu K, Woo JT, Iseki S, Ota MS. Harmine promotes molar root development via SMAD1/5/8 phosphorylation. Biochem Biophys Res Commun. 2018 Mar 11;497(3):924-929. doi: 10.1016/j.bbrc.2017.12.062. Epub 2017 Dec 15. PMID: 29253570.

Weng Y, Mizuno N, Dong J, Segawa R, Yonezawa T, Cha BY, Woo JT, Moriya T, Hiratsuka M, Hirasawa N. Induction of thymic stromal lymphopoietin by a steroid alkaloid derivative in mouse keratinocytes. Int Immunopharmacol. 2018 Feb;55:28-37. doi: 10.1016/j.intimp.2017.11.045. Epub 2017 Dec 22. PMID: 29220720.

Minami M, Mori T, Yonezawa T, Saito Y, Teruya T, Woo JT. Evaluation of raw nepodin extraction from Rumex japonicus and R. obtusifolius and their DNA polymorphisms. J Nat Med. 2018 Jan;72(1):369-374. doi: 10.1007/s11418-017-1143-0. Epub 2017 Oct 23. PMID: 29063361.

Kim NT, Lee DS, Chowdhury A, Lee H, Cha BY, Woo JT, Woo ER, Jang JH. Acerogenin C from Acer nikoense exhibits a neuroprotective effect in mouse hippocampal HT22 cell lines through the upregulation of Nrf-2/HO-1 signaling pathways. Mol Med Rep. 2017 Aug;16(2):1537-1543. doi: 10.3892/mmr.2017.6682. Epub 2017 Jun 2. PMID: 28586034.

Kim YJ, Choi MS, Woo JT, Jeong MJ, Kim SR, Jung UJ. Long-term dietary supplementation with low-dose nobiletin ameliorates hepatic steatosis, insulin resistance, and inflammation without altering fat mass in diet-induced obesity. Mol Nutr Food Res. 2017 Aug;61(8). doi: 10.1002/mnfr.201600889. Epub 2017 Mar 2. PMID: 28116779.

Eun SH, Woo JT, Kim DH. Tangeretin Inhibits IL-12 Expression and NF-κB Activation in Dendritic Cells and Attenuates Colitis in Mice. Planta Med. 2017 Apr;83(6):527-533. doi: 10.1055/s-0042-119074. Epub 2016 Nov 2. PMID: 27806407.

Lee DS, Cha BY, Woo JT, Kim YC, Jang JH. Acerogenin A from Acer nikoense Maxim Prevents Oxidative Stress-Induced Neuronal Cell Death through Nrf2-Mediated Heme Oxygenase-1 Expression in Mouse Hippocampal HT22 Cell Line. Molecules. 2015 Jul 9;20(7):12545-57. doi: 10.3390/molecules200712545. PMID: 26184139; PMCID: PMC6331826.

Kim HJ, Kim JS, Woo JT, Lee IS, Cha BY. Hyperpigmentation mechanism of methyl 3,5-di-caffeoylquinate through activation of p38 and MITF induction of tyrosinase. Acta Biochim Biophys Sin (Shanghai). 2015 Jul;47(7):548-56. doi: 10.1093/abbs/gmv040. Epub 2015 May 27. PMID: 26018825.

Kim HJ, Kim IS, Dong Y, Lee IS, Kim JS, Kim JS, Woo JT, Cha BY. Melanogenesis -inducing effect of cirsimaritin through increases in microphthalmia-associated transcription factor and tyrosinase expression. Int J Mol Sci. 2015 Apr 20;16(4):8772-88. doi: 10.3390/ijms16048772. PMID: 25903150; PMCID: PMC4425108.

Kim HJ, Yonezawa T, Teruya T, Woo JT, Cha BY. Nobiletin, a polymethoxy flavonoid, reduced endothelin-1 plus SCF-induced pigmentation in human melanocytes. Photochem Photobiol. 2015 Mar-Apr;91(2):379-86. doi: 10.1111/php.12400. Epub 2015 Jan 12. PMID: 25488359.

Lee JW, Asai M, Jeon SK, Iimura T, Yonezawa T, Cha BY, Woo JT, Yamaguchi A. Rosmarinic acid exerts an antiosteoporotic effect in the RANKL-induced mouse model of bone loss by promotion of osteoblastic differentiation and inhibition of osteoclastic differentiation. Mol Nutr Food Res. 2015 Mar;59(3):386-400. doi: 10.1002/mnfr. 201400164. Epub 2015 Jan 21. PMID: 25380345.

Ha BG, Yonezawa T, Son MJ, Woo JT, Ohba S, Chung UI, Yagasaki K. Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo. Biofactors. 2014 Jul-Aug;40(4):436-47. doi: 10.1002/biof.1165. Epub 2014 Apr 23. PMID: 24756979.


Bone Resorption Inhibitor, Japan Patent 11-246406, 1998

Bone Resorption Inhibitor, Japan Patent 11-246405, 1998

Cysteine Protease Inhibitors, Bone Resorption Inhibitors and Peptide Derivatives, Japan Patent 08-092193, 1996

Polygalacturonase Inhibitors, Japan Patent 08-081489, 1996

Bioactive Peptide Compounds, Japan Patent 07-070098, 1995

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