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Title Professor
Belong to Dept. of Biological Chemistry
Bioscience and Biotechnology (graduate school)
Graduated Tohoku University, Graduate School of Medicine
Degree Dr. of Medicine, Tohoku University
Academic Institutional Membership The Japanese Biochemical Society, The Molecular Biology Society of Japan, The Japanese Cancer Association
Field of Study Molecular Biology, Biochemistry
Research, Studies Investigation of Roles of Protein Phosphatases in Regulation of Cell Signaling
Curriculum Specialized Achievements in Study & Education:

Books Published, Translation

The Structure and Function of Protein Phosphatases, Kyoritsu Shuppan, 1998

Academic Papers, Critique

Targeted disruption of the mouse protein phosphatase ppm1l gene leads to structural abnormalities in the brain. FEBS Lett.590(20):3606-3615, 2016.

Calcineurin inhibitors suppress the high-temperature stress sensitivity of the yeast ubiquitin ligase Rsp5 mutant: a new method of screening for calcineurin inhibitors. FEMS Yeast Res.14(4):567-74, 2014.

Pisiferdiol restores the growth of a mutant yeast suffering from hyperactivated Ca2+ signalling through calcineurin inhibition. FEMS Yeast Res.13(1):16-22, 2013.

Effects of veraguensin and galgravin on osteoclast differentiation and function. Cytotechnology.64(3):315-22, 2012.

Inhibitory effects of wasabi isothiocyanates on chemical mediator release in RBL-2H3 rat basophilic leukemia cells. J Nutr Sci Vitaminol (Tokyo).58(4):303-7, 2012.

Sanguinarine as a potent and specific inhibitor of protein phosphatase 2C in vitro and induces apoptosis via phosphorylation of p38 in HL60 cells. Biosci Biotechnol Biochem.74(3):548-52, 2010.

Pisiferdiol and pisiferic acid isolated from Chamaecyparis pisifera activate protein phosphatase 2C in vitro and induce caspase-3/7-dependent apoptosis via dephosphorylation of Bad in HL60 cells. Phytomedicine.17(10):782-8, 2010.

Disruption of the mouse protein Ser/Thr phosphatase 2Cbeta gene leads to early pre-implantation lethality. Mech Dev.;124(6), 2007.

Cadmium cation increases the production and mRNA levels of insulin-like growth factor-binding protein-1 in HepG2. Biosci Biotechnol Biochem. 71(5), 2007

Quercetin suppresses bone resorption by inhibiting differentiation and activation of osteoclasts. Biological Pharm Bull. Vol. 27, 2004

Molecular cloning of PP2Ceta, a novel member of the protein phosphatase 2C family. Biochim. Biophys. Acta. Vol. 1630, 2003

A novel protein phosphatase 2C family member(PP2Czeta) is able to associate with ubiquitin conjugating enzyme 9. FEBS Lett. Vol. 538, 2003

Regulation of stress-activated protein kinase signaling pathways by protein phospjatases. Eur.J.Biocham.minireview series, Eur. J. Biochem. Vol. 269, 2002

Activation of c-Jun amino-terminal kinase is required for retinoic acid-induced neural differentiation of P19 embryonal carcinoma cells REBS Lett. Vol.503, 2001

Regulation of the TAKI signaling pathway by protein phosphatase 2C J.Bill.Chem.Vol.276, 2001

Lectures, Symposium, Presentation

Activation of Protein phosphatase 2C by Pisiferdiol. Annual meeting of Japan Society for Bioscience, Biotechnology, and Agrochemistry, 2008

The role of protein phosphatases in differentiation of osteoclasts. Symposium of the 150th meeting of Kansai and Chubu Branchs, 2007

The role of PP2C beta and epsilon in RANKL/RANK Signal Transduction pathway. The 3rd meeting of Japanese Association for Protein Phosphatase Research, 2007

Protein phosphatase 2Cβ and ε suppress the RANKL/RANK Signaling Pathway. International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress, 2006

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