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Title Associate Professor
Belong to Dept. of Physical Therapy
Dept. of Biomedical Sciences
Center for Physical Therapy Practicum Support
Biomedical Sciences (graduate school)
Graduated Nagoya University, Graduate School of Medicine
Degree Doctor of Philosophy (Medical Science)
Field of Study Immunology, Molecular biology
Research, Studies redox-mediated tyrosine kinase activation, tumor regulator

Academic Papers, Critique

Peptides containing the MXXCW motif inhibit oncogenic RET kinase activity with a novel mechanism of action. Takeda K, Kawamoto Y, Nagasaki Y, Okuno Y, Goto Y, Iida M, Yajima I, Ohgami N, Kato M. Am J Cancer Res. 2020 Jan 1;10(1):336-349.

Inhibition of mast cell degranulation by melanin. Kawamoto Y, Kondo H, Hasegawa M, Kurimoto C, Ishii Y, Kato C, Botei T, Shinya M, Murate T, Ueno Y, Kawabe M, Goto Y, Yamamoto R, Iida M, Yajima I, Ohgami N, Kato M, Takeda K. Biochem Pharmacol. 2019 May;163:178-193.

Improvement of balance in young adults by a sound component at 100 Hz in music. Xu H, Ohgami N, He T, Hashimoto K, Tazaki A, Ohgami K, Takeda K, Kato M. Sci Rep. 2018 Nov 15;8(1):16894.

The effects of non-thermal atmospheric pressure plasma irradiation on expression levels of matrix metalloproteinases in benign melanocytic tumors in RET-transgenic mice. Iida M, Yajima I, Ohgami N, Tamura H, Takeda K, Ichihara S, Hori M, Kato M. Eur J Dermatol. 2014 May-Jun;24(3):392-4.

Control of genetically prescribed protein tyrosine kinase activities by environment-linked redox reactions. Nakashima I, Kawamoto Y, Takeda K, Kato M. Enzyme Res. 2011.

L-cysteine as a regulator for arsenic-mediated cancer-promoting and anti-cancer effects. Kato M, Kumasaka MY, Takeda K, Hossain K, Iida M, Yajima I, Goto Y, Ohgami N. Toxicol In Vitro. 2011; 25(3):623-9

c-RET molecule in malignant melanoma from oncogenic RET-carrying transgenic mice and human cell lines. Ohshima Y, Yajima I, Takeda K, Iida M, Kumasaka M, Matsumoto Y, Kato M. PLoS One. 2010; 5(4):e10279.

A redox-linked novel pathway for arsenic-mediated RET tyrosine kinase activation. Kato M, Takeda K, Hossain K, Thang ND, Kaneko Y, Kumasaka M, Yamanoshita O, Uemura N, Takahashi M, Ohgami N, Kawamoto Y. J Cell Biochem. 2010; 110(2):399-407.

Induction of autoimmunity in a bleomycin-induced murine model of experimental systemic sclerosis: an important role for CD4+ T cells. Ishikawa H, Takeda K, Okamoto A, Matsuo S, Isobe K. J Invest Dermatol. 2009; 129(7):1688-95.

The vacuolar V1/V0-ATPase is involved in the release of the HOPS subunit Vps41 from vacuoles, vacuole fragmentation and fusion. Takeda K, Cabrera M, Rohde J, Bausch D, Jensen ON, Ungermann C. FEBS Lett. 2008; 582(10):1558-63.

Novel hairless RET-transgenic mouse line with melanocytic nevi and anagen hair follicles. Kato M, Takeda K, Kawamoto Y, Tsuzuki T, Kato Y, Ohno T, Hossain K, Iftakhar-E-Khuda I, Ohgami N, Isobe K, Takahashi M, Nakashima I. J Invest Dermatol. 2006; 126(11):2547-50.

A PKC-mediated backup mechanism of the MXXCW motif-linked switch for initiating tyrosine kinase activities. Takeda K, Kawamoto Y, Okuno Y, Kato M, Takahashi M, Suzuki H, Isobe K, Nakashima I. FEBS Lett. 2006; 580(3):839-43.

CD8+CD122+ regulatory T cells produce IL-10 to suppress IFN-gamma production and proliferation of CD8+ T cells. Endharti AT, Rifa'I M, Shi Z, Fukuoka Y, Nakahara Y, Kawamoto Y, Takeda K, Isobe K, Suzuki H. J Immunol. 2005; 175(11):7093-7.

Paeoniflorin induces apoptosis of lymphocytes through a redox-linked mechanism. Tsuboi H, Hossain K, Akhand AA, Takeda K, Du J, Rifa'i M, Dai Y, Hayakawa A, Suzuki H, Nakashima I. J Cell Biochem. 2004; 93(1):162-72.

c-Kit-targeting immunotherapy for hereditary melanoma in a mouse model. Kato M, Takeda K, Kawamoto Y, Tsuzuki T, Hossain K, Tamakoshi A, Kunisada T, Kambayashi Y, Ogino K, Suzuki H, Takahashi M, Nakashima I. Cancer Res. 2004; 64(3):801-6.

Identification of RET autophosphorylation sites by mass spectrometry. Kawamoto Y, Takeda K, Okuno Y, Yamakawa Y, Ito Y, Taguchi R, Kato M, Suzuki H, Takahashi M, Nakashima I. J Biol Chem. 2004; 279(14):14213-24.

Protein phosphatase 2A-linked and -unlinked caspase-dependent pathways for downregulation of Akt kinase triggered by 4-hydroxynonenal. Liu W, Akhand AA, Takeda K, Kawamoto Y, Itoigawa M, Kato M, Suzuki H, Ishikawa N, Nakashima I. Cell Death Differ. 2003; 10(7):772-81.

Repair by Src kinase of function-impaired RET with multiple endocrine neoplasia type 2A mutation with substitutions of tyrosines in the COOH-terminal kinase domain for phenylalanine. Kato M, Takeda K, Kawamoto Y, Iwashita T, Akhand AA, Senga T, Yamamoto M, Sobue G, Hamaguchi M, Takahashi M, Nakashima I. Cancer Res. 2002; 62(8):2414-22.

RET tyrosine kinase enhances hair growth in association with promotion of melanogenesis. Kato M, Takeda K, Kawamoto Y, Tsuzuki T, Dai Y, Nakayama S, Toriyama K, Tamada Y, Takahashi M, Nakashima I. Oncogene. 2001; 20(51):7536-41.

T-cell-immunity-based inhibitory effects of orally administered herbal medicine juzen-taiho-to on the growth of primarily developed melanocytic tumors in RET-transgenic mice. Dai Y, Kato M, Takeda K, Kawamoto Y, Akhand AA, Hossain K, Suzuki H, Nakashima I. J Invest Dermatol. 2001; 117(3):694-701.

Osmotic stress-mediated activation of RET kinases involves intracellular disulfide-bonded dimer formation. Takeda K, Kato M, Wu J, Iwashita T, Suzuki H, Takahashi M, Nakashima I. Antioxid Redox Signal. 2001; 3(3):473-82.

Ultraviolet radiation induces both full activation of ret kinase and malignant melanocytic tumor promotion in RFP-RET-transgenic mice. Kato M, Liu W, Akhand AA, Hossain K, Takeda K, Takahashi M, Nakashima I. J Invest Dermatol. 2000; 115(6):1157-8.

Arsenite induces apoptosis of murine T lymphocytes through membrane raft-linked signaling for activation of c-Jun amino-terminal kinase. Hossain K, Akhand AA, Kato M, Du J, Takeda K, Wu J, Takeuchi K, Liu W, Suzuki H, Nakashima I. J Immunol. 2000; 165(8):4290-7.

Ultraviolet light induces redox reaction-mediated dimerization and superactivation of oncogenic Ret tyrosine kinases. Kato M, Iwashita T, Takeda K, Akhand AA, Liu W, Yoshihara M, Asai N, Suzuki H, Takahashi M, Nakashima I. Mol Biol Cell. 2000; 11(1):93-101.

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