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SOBUE Sayaka


Title Associate Professor
Belong to Center for Clinical Examination Practicum Support
Dept. of Biomedical Sciences
Graduated Nagoya University, Graduate School of Medicine
Degree Dr. of Medical Technology, Nagoya University
Qualification Biomedical laboratory scientist
Academic Institutional Membership The molecular Biology Society of Japan
The Japanese Biochemical Society
The Japanese Society for Laboratory Hematology
Field of Study Cell biology, Molecular Biology, Pathology
Research, Studies Analysis of biological effects of molecular hydrogen
Curriculum Specialized Intensive Blood Morphology, General Clinical Technology II

Academic Papers, Critique

Sobue S, Inoue C, Hori F, Qiao S, Murate T, Ichihara M. Molecular hydrogen modulates gene expression via histone modification and induces the mitochondrial unfolded protein response. Biochem Biophys Res Commun. 2017; 493: 318-324.

Sobue S, Mizutani N, Aoyama Y, Kawamoto Y, Suzuki M, Nozawa Y, Ichihara M, Murate T. Mechanism of paclitaxel resistance in a human prostate cancer cell line, PC3-PR, and its sensitization by cabazitaxel. Biochem Biophys Res Commun. 2016; 479: 808-813.

Sobue S, Sakata K, Sekijima Y, Qiao S, Murate T, Ichihara M. Characterization of gene expression profiling of mouse tissues obtained during the postmortem interval. Exp Mol Pathol. 2016; 100: 482-492.

Sobue S, Yamai K, Ito M, Ohno K, Ito M, Iwamoto T, Qiao S, Ohkuwa T, Ichihara M. Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents. Mol Cell Biochem. 2015; 403: 231-241.

Sobue S, Murakami M, Banno Y, Ito H, Kimura A, Gao S, Furuhata A, Takagi A, Kojima T, Suzuki M, Nozawa Y, Murate T. v-Src oncogene product increases sphingosine kinase 1 expression through mRNA stabilization: alteration of AU-rich element-binding proteins. Oncogene. 2008; 27: 6023-6033.

Sobue S, Nemoto S, Murakami M, Ito H, Kimura A, Gao S, Furuhata A, Takagi A, Kojima T, Nakamura M, Ito Y, Suzuki M, Banno Y, Nozawa Y, Murate T. Implications of sphingosine kinase 1 expression level for the cellular sphingolipid rheostat: relevance as a marker for daunorubicin sensitivity of leukemia cells. Int J Hematol. 2008; 87: 266-275.

Sobue S, Iwasaki T, Sugisaki C, Nagata K, Kikuchi R, Murakami M, Takagi A, Kojima T, Banno Y, Akao Y, Nozawa Y, Kannagi R, Suzuki M, Abe A, Naoe T, Murate T. Quantitative RT-PCR analysis of sphingolipid metabolic enzymes in acute leukemia and myelodysplastic syndromes. Leukemia. 2006; 20: 2042-2046.

Sobue S, Hagiwara K, Banno Y, Tamiya-Koizumi K, Suzuki M, Takagi A, Kojima T, Asano H, Nozawa Y, Murate T. Transcription factor specificity protein 1 (Sp1) is the main regulator of nerve growth factor-induced sphingosine kinase 1 gene expression of the rat pheochromocytoma cell line, PC12. J Neurochem. 2005; 95: 940-949.

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