SHIMOMURA Yoshiharu

Profile

Year of Birth	1953
Place of Birth	Aichi
Title	Professor
Belong to	Dept. of Food and Nutritional Sciences Center for Registered Dietitian Practicum Support Bioscience and Biotechnology (graduate school) Nutritional Health Science Research Center
Graduated	Nagoya University Graduate School of Medicine
Degree	Ph.D.
Academic Institutional Membership	Japan Society of Nutrition and Food Science, Advisor (President 2016-2017) Japanese Society for Amino Acid Sciences, Advisor (President 2011-2014)
Field of Study	Nutritional Biochemistry
Research, Studies	Regulation of branched-chain amino acid (BCAA) catabolism and physiological functions of BCAA
Curriculum Specialized	Branched-chain amino acids, fructooligosaccharides

Academic Papers, Critique

Bacteroides spp. promotes branched-chain amino acid catabolism in brown fat and inhibits obesity. iScience. 2021 Oct 24;24(11):103342. doi: 10.1016/j.isci.2021.103342.

Branched-chain amino acids regulate hyaluronan synthesis and PPARα expression in the skin. Biosci Biotechnol Biochem. 2021 Nov;85(11):2292-4. doi: 10.1093/bbb/zbab160.

Supplementation of 1-kestose modulates the gut microbiota composition to ameliorate glucose metabolism in obesity-prone hosts. Nutrients. 2021; 13: 2983. doi.org/10.3390/nu13092983.

Tolerable amounts of amino acids for human supplementation: summary and lessons from published peer-reviewed studies. Amino Acids. 2021 Aug 2. doi: 10.1007/s00726-021-03054-z.

Antihypertensive drug valsartan as a novel BDK inhibitor. Pharmacol Res. 2021 Feb 24;167: 105518. doi: 10.1016/j.phrs.2021.105518.

1-Kestose supplementation mitigates the progressive deterioration of glucose metabolism in type 2 diabetes OLETF rats. Sci Rep. 2020 Sep 24; 10(1): 15674. doi: 10.1038/s41598-020-72773-2.

BDK deficiency in cerebral cortex neurons causes neurological abnormalities and affects endurance capacity. Nutrients. 2020, 12, 2267. doi: 10.3390/nu12082267.

Branched-chain amino acid supplementation ameliorates angiotensin II-induced skeletal muscle atrophy. Life Sci. 2020 Jun 1;250:117593. doi: 10.1016/j.lfs.2020.117593.

Experimental determination of the threshold dose for bifidogenic activity of dietary 1-kestose in rats. Foods. 2019 Dec 19;9(1):4. doi: 10.3390/foods9010004.

Feeding of 1-kestose induces glutathione-S-transferase expression in mouse liver. Foods. 2019 Feb 13;8(2): E69. doi: 10.3390/foods8020069.

Ca2+-dependent inhibition of branched-chain α-ketoacid dehydrogenase kinase by thiamine pyrophosphate. Biochem Biophys Res Commun. 2018 Oct 12;504(4):916-920. doi: 10.1016/j.bbrc.2018.09.038.

Physiological and pathological roles of branched-chain amino acids in the regulation of protein and energy metabolism and neurological functions. Pharmacol Res. 2018 Jul;133:215-217. doi: 10.1016/j.phrs.2018.05.014.

Branched-chain amino acid (BCAA) supplementation enhances adaptability to exercise training of mice with a muscle-specific defect in the control of BCAA catabolism. Biosci Biotechnol Biochem. 2018 Mar 1:1-4. doi: 10.1080/09168451.2018.1440174.

Endurance performance and energy metabolism during exercise in mice with a muscle-specific defect in the control of branched-chain amino acid catabolism. PLoS One. 2017 Jul 18;12(7):e0180989. doi: 10.1371/journal.pone.0180989.

Branched-chain amino acids alleviate hepatic steatosis and liver injury in choline-deficient high-fat diet induced NASH mice. Metabolism, 2017, 69:177-187. doi: 10.1016/j.metabol.2016.12.013.

Muscle-specific deletion of BDK amplifies loss of myofibrillar protein during protein undernutrition. Sci Rep. 2017 Jan 4;7:39825. doi: 10.1038/srep39825.

An alteration in the cecal microbiota composition by feeding of 1-kestose results in a marked increase in the cecal butyrate content in rats. PLoS One. 2016 Nov 18;11(11):e0166850. doi: 10.1371/journal.pone.0166850.

Clinical, biochemical, and metabolic characterization of a mild form of human short-chain enoyl-CoA hydratase deficiency: significance of increased N-acetyl-S-(2-carboxypropyl)cysteine excretion. J Med Genet. 52(10): 691-698. doi: 10.1136/jmedgenet-2015-103231.

Octanoic acid promotes branched-chain amino acid catabolism via the inhibition of hepatic branched-chain alpha-keto acid dehydrogenase kinase in rats. Metabolism. 64(9):1157-1164. doi: 10.1016/j.metabol.2015.05.014.

Clinical and biochemical characterization of 3-hydroxyisobutyryl-CoA hydrolase (HIBCH) deficiency that causes Leigh-like disease and ketoacidosis. Mol Genet Metab Rep. 2014 Oct 16;1:455-460. eCollection 2014.

Awards

Japan Society of Nutrition and Food Science (JSNFS) Award for Excellence in Research (2011)

Ajinomoto Award for BCAA Basic Research (2001)