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QIAO Shanlou


Title Professor
Belong to Dept. of Biomedical Sciences
Center for Clinical Examination Practicum Support
Biomedical Sciences (graduate school)
Graduated Nagoya University, Graduate School of Medicine
Degree Doctor of Medicine
Academic Institutional Membership The Japanese Society of Pathology
The Japanese Biochemical Society
Field of Study Pathology, Oncology, Cell Biology
Research, Studies Our research goal is to identify the mechanisms by which the tumour microenvironment impacts on the initiation and progression of cancers, and discover anticancer agents from natural sources by targeting the tumor microenvironment for cancer therapy
Curriculum Specialized Pathology

Academic Papers, Critique

34. Nisimoto, Y., Ogawa, H., Kadokawa, Y., and Qiao, S. (2018) NADPH oxidase 4 function as a hydrogen peroxide sensor. J Biochem 163, 489-501

33. Sobue, S., Inoue, C., Hori, F., Qiao, S., Murate, T., and Ichihara, M. (2017) Molecular hydrogen modulates gene expression via histone modification and induces the mitochondrial unfolded protein response. Biochem Biophys Res Commun 493, 318-324

32. Kawamoto, Y., Ueno, Y., Nakahashi, E., Obayashi, M., Sugihara, K., Qiao, S., Iida, M., Kumasaka, M. Y., Yajima, I., Goto, Y., Ohgami, N., Kato, M., and Takeda, K. (2016) Prevention of allergic rhinitis by ginger and the molecular basis of immunosuppression by 6-gingerol through T cell inactivation. J Nutr Biochem 27, 112-122

31. Sobue, S., Sakata, K., Sekijima, Y., Qiao, S., Murate, T., and Ichihara, M. (2016) Characterization of gene expression profiling of mouse tissues obtained during the postmortem interval. Exp Mol Pathol 100, 482-492

30. Sobue, S., Yamai, K., Ito, M., Ohno, K., Ito, M., Iwamoto, T., Qiao, S., Ohkuwa, T., and Ichihara, M. (2015) Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents. Molecular and cellular biochemistry 403, 231-241

29. Yamashita, S. K., S.;Takeuchia, T.; Qiao, S.; Tsutsumiuchib K.; Wang, T.; Wang, Y. (2015) Dietary supplementation with evodiamine prevents obesity and improves insulin resistance in ageing mice. Journal of Functional Foods Volume 19, Part A, 320–329

28. Shanlou Qiao, K. F., Toshihide Iwashita, Takashi Iwamoto, Hitoshi Yamashita, Masatoshi Ichihara, Masataka Yoshino, Yukio Nisimoto, Masahide Takahashi. (2014. 9) The involvement of reactive oxygen species derived from NADPH Oxidase-1 activation in the constitutive tyrosine auto-phosphorylation of RET proteins in 86th the Japanese Society of Pathology

27. Qiao, S., Fan, K., Iwashita, T., Ichihara, M., Yoshino, M., and Takahashi, M. (2014) The involvement of reactive oxygen species derived from NADPH oxidase-1 activation on the constitutive tyrosine auto-phosphorylation of RET proteins. Free Radic Res 48, 427-434

26. Takaoka, Y., Shimizu, Y., Hasegawa, H., Ouchi, Y., Qiao, S., Nagahara, M., Ichihara, M., Lee, J. D., Adachi, K., Hamaguchi, M., and Iwamoto, T. (2012) Forced expression of miR-143 represses ERK5/c-Myc and p68/p72 signaling in concert with miR-145 in gut tumors of Apc(Min) mice. PLoS One 7, e42137

25. Mirza, R., Qiao, S., Tateyama, K., Miyamoto, T., Xiuli, L., and Seo, H. (2012) 3beta-Hydroxysterol-Delta24 reductase plays an important role in long bone growth by protecting chondrocytes from reactive oxygen species. J Bone Miner Metab 30, 144-153 (#Co-first author)

24. Qiao, S., Murakami, K., Zhao, Q., Wang, B., Seo, H., Yamashita, H., Li, X., Iwamoto, T., Ichihara, M., and Yoshino, M. (2012) Mimosine-induced apoptosis in C6 glioma cells requires the release of mitochondria-derived reactive oxygen species and p38, JNK activation. Neurochem Res 37, 417-427 (*Corresponding author)

23. Suzawa, N., Ito, M., Qiao, S., Uchida, K., Takao, M., Yamada, T., Takeda, K., and Murashima, S. (2011) Assessment of factors influencing FDG uptake in non-small cell lung cancer on PET/CT by investigating histological differences in expression of glucose transporters 1 and 3 and tumour size. Lung Cancer 72, 191-198

22. Liu, J., Yu, G., Zhao, Y., Zhao, D., Wang, Y., Wang, L., Li, L., Zeng, Y., Dang, Y., Wang, C., Gao, G., Long, W., Lonard, D. M., Qiao, S., Tsai, M. J., Zhang, B., Luo, H., and Li, X. (2010) REG{gamma} modulates p53 activity by regulating its cellular localization. J Cell Sci 123, 4076-4084

21. Qiao, S., Iwashita, T., Ichihara, M., Murakumo, Y., Yamaguchi, A., Isogai, M., Sakata, K., and Takahashi, M. (2009) Increased expression of glial cell line-derived neurotrophic factor and neurturin in a case of colon adenocarcinoma associated with diffuse ganglioneuromatosis. Clin Neuropathol 28, 105-112 (*Corresponding author)

20. Murakami, K., Tsubouchi, R., Fukayama, M., Qiao, S., and Yoshino, M. (2009) Iron-dependent oxidative inactivation with affinity cleavage of pyruvate kinase. Biol Trace Elem Res 130, 31-38

19. Mirza, R., Qiao, S., Murata, Y., and Seo, H. (2009) Requirement of DHCR24 for postnatal development of epidermis and hair follicles in mice. Am J Dermatopathol 31, 446-452

18. Nisimoto, Y., Tsubouchi, R., Diebold, B. A., Qiao, S., Ogawa, H., Ohara, T., and Tamura, M. (2008) Activation of NADPH oxidase 1 in tumour colon epithelial cells. Biochem J 415, 57-65

17. Matsushima, N., Kobayashi, S., Kozuka, Y., Ito, M., Qiao, S., and Takeda, K. (2008) Comparative study of 18F-FDG uptake, glucose transporter-1,3 overexpression and tumor volume in primary cancer of uterus. J Nucl Med. 49, 353

16. Nobuyoshi Matsushima, S. K., Yuji Kozuka, Morihiro Ito, Shanlou Qiao and Kan Takeda. (2008) Comparative study of 18F-FDG uptake, glucose transporter-1,3 overexpression and tumor volume in primary cancer of uterus. J Nucl Med. 49, 353P

15. Murakami, K., Haneda, M., Qiao, S., Naruse, M., and Yoshino, M. (2007) Prooxidant action of rosmarinic acid: transition metal-dependent generation of reactive oxygen species. Toxicol In Vitro 21, 613-617

14. Ichihara, M., Murakumo, Y., Masuda, A., Matsuura, T., Asai, N., Jijiwa, M., Ishida, M., Shinmi, J., Yatsuya, H., Qiao, S., Takahashi, M., and Ohno, K. (2007) Thermodynamic instability of siRNA duplex is a prerequisite for dependable prediction of siRNA activities. Nucleic Acids Res 35, e123

13. Suzawa, N., Murashima, S., Ito, M., Qiao, S., and Takeda, K. (2007) Histological difference in overexpression of Glut-3 and Glut-1 assessed by immunohistochemical staining in non-small cell lung cancer: Comparative study with FDG PET-CT. J Nucl Med. 48, 352

12. Li, W., Tsubouchi, R., Qiao, S., Haneda, M., Murakami, K., and Yoshino, M. (2006) Inhibitory action of eugenol compounds on the production of nitric oxide in RAW264.7 macrophages. Biomed Res 27, 69-74

11. Qiao, S., Li, W., Tsubouchi, R., Haneda, M., Murakami, K., Takeuchi, F., Nisimoto, Y., and Yoshino, M. (2005) Rosmarinic acid inhibits the formation of reactive oxygen and nitrogen species in RAW264.7 macrophages. Free Radic Res 39, 995-1003 (*Corresponding author)

10. Qiao, S., Li, W., Tsubouchi, R., Haneda, M., Murakami, K., and Yoshino, M. (2005) Involvement of peroxynitrite in capsaicin-induced apoptosis of C6 glioma cells. Neurosci Res 51, 175-183 (*Corresponding author)

9. Nishio, K., Qiao, S., and Yamashita, H. (2005) Characterization of the differential expression of uncoupling protein 2 and ROS production in differentiated mouse macrophage-cells (Mm1) and the progenitor cells (M1). J Mol Histol 36, 35-44 (#Co-first author)

8. Yoshino, M., Haneda, M., Naruse, M., Htay, H. H., Tsubouchi, R., Qiao, S., Li, W. H., Murakami, K., and Yokochi, T. (2004) Prooxidant activity of curcumin: copper-dependent formation of 8-hydroxy-2'-deoxyguanosine in DNA and induction of apoptotic cell death. Toxicol In Vitro 18, 783-789

7. Qiao, S., Li, W., Tsubouchi, R., Murakami, K., and Yoshino, M. (2004) Role of vanilloid receptors in the capsaicin-mediated induction of iNOS in PC12 cells. Neurochem Res 29, 687-693 (*Corresponding author)

6. Nishio, K., Inoue, A., Qiao, S., Kondo, H., and Mimura, A. (2001) Senescence and cytoskeleton: overproduction of vimentin induces senescent-like morphology in human fibroblasts. Histochem Cell Biol 116, 321-327

5. Qiao, S., Iwashita, T., Furukawa, T., Yamamoto, M., Sobue, G., and Takahashi, M. (2001) Differential effects of leukocyte common antigen-related protein on biochemical and biological activities of RET-MEN2A and RET-MEN2B mutant proteins. J Biol Chem 276, 9460-9467

4. Iwashita, T., Kurokawa, K., Qiao, S., Murakami, H., Asai, N., Kawai, K., Hashimoto, M., Watanabe, T., Ichihara, M., and Takahashi, M. (2001) Functional analysis of RET with Hirschsprung mutations affecting its kinase domain. Gastroenterology 121, 24-33

3. Iwashita, T., Murakami, H., Kurokawa, K., Kawai, K., Miyauchi, A., Futami, H., Qiao, S., Ichihara, M., and Takahashi, M. (2000) A two-hit model for development of multiple endocrine neoplasia type 2B by RET mutations. Biochem Biophys Res Commun 268, 804-808

2. Qiao, S., Nagasaka, T., Harada, T., and Nakashima, N. (1998) p53, Bax and Bcl-2 expression, and apoptosis in gestational trophoblast of complete hydatidiform mole. Placenta 19, 361-369 (*Corresponding author)

1. Qiao, S., Nagasaka, T., and Nakashima, N. (1997) Numerous vessels detected by CD34 in the villous stroma of complete hydatidiform moles. International Journal of Gynecological Pathology 16, 233-238 (*Corresponding author)

Social Activities

Annual Meeting of the Japanese Biochemical Society

Annual Meeting of the Japanese Society of Pathology

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