YAMASHITA Hitoshi

Profile

Year of Birth	1957
Place of Birth	Nagoya, Aichi
Title	Professor
Belong to	Dept. of Biomedical Sciences Center for Clinical Examination Practicum Support Biomedical Sciences (graduate school)
Graduated	Nagoya University, School of Agricultural Sciences
Degree	Ph.D
Academic Institutional Membership	Japanese Societies of Molecular Biology The Japanese Biochemical Society The Japan Society for Biomedical Gerontology (Board) Japan Society for the Study of Obesity (Board)
Field of Study	Molecular Genetics, Biomedical Gerontology
Research, Studies	Mechanisms of thermoregulation, energy metabolism and aging
Curriculum Specialized	Molecular Biology, Genome Science

Academic Papers, Critique

CREG1 improves diet-induced obesity via uncoupling protein 1-dependent manner in mice. Genes to Cells, 27:202-213, 2022.

CREG1 administration stimulates BAT thermogenesis and improves diet-induced obesity in mice. J Biochem., 171(1):63-73, 2022.

Effects of CREG1 on age-associated metabolic phenotypes and renal senescence in mice. Int. J. Mol. Sci., 22(3), 1276, 2021

High temperature promotes amyloid β-protein production and γ-secretase complex formation via Hsp90. J Biol Chem., 295(52):18010-18022, 2020

Dietary Supplementation with Dunaliella Tertiolecta Prevents Whitening of Brown Fat and Controls Diet-Induced Obesity at Thermoneutrality in Mice. Nutrients 12(6):1686, 2020

Lack of UCP1 stimulates fatty liver but mediates UCP1-independent action of beige fat to improve hyperlipidemia in Apoe knockout mice. BBA Molecular Basis of Disease. 2020.165762

CREG1 stimulates brown adipocyte formation and ameliorates diet-induced obesity in mice. FASEB J., 33(7):8069-8082, 2019

Brown adipocytes and β3-stimulant-induced brown-like adipocytes contribute to the prevention of renal crystal formation. Am J Physiol Renal Physiol. 2019 Jun 1;316(6):F1282-F1292, 2019

CREG1 promotes uncoupling protein 1 expression and brown adipogenesis in vitro. J Biochem., Jan 1;165(1):47-55, 2019

Asp3Gly polymorphism affects fatty acid-binding protein 3 intracellular stability and subcellular localization. FEBS Lett., 589: 2382-2387, 2015

Dietary supplementation with evodiamine prevents obesity and improves insulin resistance in ageing mice. J. Funct. Foods, 19: 320-329, 2015

A natural compound Evo(kes) signaling for fat regulation. Cell Cycle, Vol.13, 2014

Evodiamine inhibits insulin-stimulated mTOR-S6K activation and IRS1 serine phosphorylation in adipocytes and improves glucose tolerance in obese/diabetic mice. PLoS ONE, Vol.8, 2013

TRPV4 deficiency increases skeletal muscle metabolic capacity and resistance against diet-induced obesity. J. Appl. Physiol., Vol.112, 2012

β3-adrenergic activation of sequential Ca2+ release from mitochondria and the endoplasmic reticulum and the subsequent Ca2+ entry in rodent brown adipocytes. Cell Calcium, Vol.49, 2011

Fatty acid-binding protein 3 stimulates glucose uptake by facilitating AS160 phosphorylation in mouse muscle cells. Genes to Cells, Vol.16, 2011

Evodiamine inhibits adipogenesis via EGFR-PKCα-ERK signaling pathway. FEBS Lett. Vol.583, 2009

Induction of fatty acid-binding protein 3 in brown adipose tissue correlates with increased demand for adaptive thermogenesis in rodents. Biochem. Biophys. Res. Commun. Vol.377, 2008

Evodiamine improves diet-induced obesity in a UCP1-independent manner: Involvement of anti-adipogenic mechanism and ERK/MAPK signaling. Endocrinol. Vol.149, 2008

Indispensable role of mitochondrial uncoupling protein 1 (UCP1) for anti-obesity effect of b3-adrenergic stimulation. Am. J. Physiol., Vol.290, 2006

Potential contribution of vasoconstriction to suppression of heat loss and homeothermic regulation in UCP1-deficient mice. Pfluger Arch.-Eur. J. Physiol., Vol.452, 2006

UCP1 deficiency increases susceptibility to diet-induced obesity with age. Aging Cell, Vol.4, 2005

Uncoupling protein 1 is necessary for norepinephrine-induced glucose utilization in brown adipose tissue. Diabetes, Vol.54, 2005

Forkhead transcription factor FOXO1 (FKHR)-dependent induction of PDK4 gene expression in skeletal muscles during energy deprivation. Biochem. J. Vol.375, 2003

Muscle type difference in the regulation of UCP3 under cold conditions. Biochem. Biophys. Res. Commun., Vol.305, 2003

Effects of aging and denervation on the expression of uncoupling proteins in slow- and fast-twitch muscles of rats. J. Biochem., Vol.132, 2002

Distinct regulation of brain mitochondrial carrier protein-1 and uncoupling protein-2 genes in the rat brain during cold exposure and aging. Biochem. Biophys. Res. Commun., Vol.278, 2000

Differences in induction of uncoupling protein genes in adipose tissues between young and old rats during cold exposure. FEBS Lett., Vol.458, 1999

Emergence of brown adipocytes in white fat in mice is under genetic control. : Effects on body weight and adiposity. J. Clin. Invest., Vol.102, 1998

Mice lacking mitochondrial uncoupling protein are cold sensitive but not obese. Nature, Vol.387, 1997

Lectures, Symposium, Presentation

Cellular Repressor of E1A-stimulated genes 1 is a novel regulator of brown adipocyte differentiation. 12th International Congress on Obesity (ICO2014), Mar 19 2014, Kuala Lumpur.

Evodiamine improves insulin resistance by inhibiting mTOR-S6K signaling in adipocytes and prevents age-related obesity in mice. 20th IAGG World Congress of Gerontology and Geriatrics (IAGG2013), Jun 23-27 2013, Seoul. Best Poster Award

Role of brown adipose tissue on the development of metabolic syndrome and aging. 1st Tri-Nations' Aging Symposium, 29th Apr., 2011, Dongguan

Evodiamine inhibits adipogenesis via ERK/MAPK signaling and prevents the development of obesity in mice. Asian Aging Core for Longevity 2010, Aug. 24. 2010, Jeju.

Role of uncoupling protein in pathogenesis of age-related disorders. Symposium: Molecular biology of Aging, The 28th Annual Meeting of the Molecular Biology Society of Japan. Dec. 9th, 2005. Fukuoka

Others

Patent

Brown adipocyte differentiation-inducing agent.(PCT/JP2013/071591)

CU12004PU, CU12004PE