中川　大　NAKAGAWA Hiroshi

プロフィール

職名	准教授
所属	応用生物学部 応用生物化学科 大学院 応用生物学研究科 応用生物学専攻
最終学歴	東京工業大学大学院生命理工学研究科
学位	博士(工学)
所属学会・役職	日本分子生物学会 日本癌学会 日本骨代謝学会 日本農芸化学会 トランスポーター研究会（幹事：2008-）
専門分野	動物細胞工学、生理遺伝学、薬理活性物質
研究テーマ	「疾患の発症」と「薬剤による副作用」の予防
授業科目	基礎化学、動物細胞工学など
共同研究キーワード	運動器、膜輸送体、遺伝子多型

著書および訳書

中川大, 禹済泰, 永井和夫., 抗骨粗鬆症, 「茶の事典」, 朝倉書店, 435-438., （2017）

Satake, K., Toyoda, Y., and Nakagawa, H., Drugs affecting epigenetics of ABC transporters for drug resistance. Thomas E., editor. Resistance to Targeted ABC Transporters in Cancer, Resistance to Targeted Anti-Cancer Therapeutics Vol. 4, Springer International Publishing Switzerland, 273-297., (2015)

中川大, 禹済泰., カテキン. 「機能性食品素材の骨と軟骨への応用」, シーエムシー出版, 141-149., （2011）

中川大, 豊田優, 中尾（若林）香菜子, 石川智久., 小胞体におけるABCトランスポーターの品質管理―ユビキチン-プロテアソーム経路による新生ABCG2蛋白質の除去―. 「遺伝子医学MOOK」, 株式会社メディカルドゥ, 19, 230-235., （2011）

中川大, 永井和夫., 破骨細胞の機能を調節する緑茶成分EGCG. 「茶の効能と応用開発」, シーエムシー出版, 196-204., （2006）

学術論文、評論

Tsukamoto, M., Yamashita, M., Nishi, T., and Nakagawa, H., A human ABC transporter ABCC4 gene SNP (rs11568658, 559 G>T, G187W) reduces ABCC4-dependent drug resistance. Cells, 8, E39., (2019)

Mitani, Y., Satake, K., Tsukamoto, M., Nakamura, I., Kadioglu, O., Teruya, T., Yonezawa, T., Cha, BY., Efferth, T., Woo, JT., and Nakagawa, H., Epimagnolin A, a tetrahydrofurofuranoid lignan from Magnolia fargesii, reverses ABCB1-mediated drug resistance. Phytomedicine, 51, 112-119., (2018)

Nakagawa, H., Toyoda, Y., Albrecht, T., Tsukamoto, M., Praetorius, M. Ishikawa, T., Kamiya, K., Kusunoki, T., Ikeda, K., and Sertel, S., Are human ATP-binding cassette transporter C11 and earwax associated with the incidence of cholesteatoma? Med. Hypotheses. 114, 19-22., (2018)

Tsukamoto, M., Sato, S., Satake, K., Miyake, M., and Nakagawa, H., Quantitative evaluation of drug resistance profile of cells expressing wild-type or genetic polymorphic variants of the human ABC transporter ABCC4. Int. Journal of Molecular Sciences. 18, E1435., (2017)

Satake, K., Tsukamoto, M., Mitani, Y., Regasini, LO., Bolzani Vda, S., Efferth, T., and Nakagawa, H., Human ABCB1 confers cells resistance to cytotoxic guanidine alkaloids from Pterogyne nitens.. Biomed. Mater. Eng., 25, 249-256., (2015)

Tajima, Y., Nakagawa, H., Tamura, A., Kadioglu, O., Satake, K., Mitani, Y., Murase, H., Regasini LO, Bolzani Vda S, Ishikawa, T., Fricker, G., and Efferth, T., Nitensidine A, a guanidine alkaloid from Pterogyne nitens, is a novel substrate for human ABC transporter ABCB1. Phytomedicine, 21, 323-332. Tajima, Y. and Nakagawa, H. contributed equally to this work., (2014)

Nakagawa, H., Toyoda, Y., Wakabayashi-Nakao, K., Tamaki, H., Osumi, M., and Ishikawa, T., Ubiquitin-mediated proteasomal degradation of ABC transporters: A new aspect of genetic polymorphisms and clinical impacts. J. Pharm. Sci., 100, 3602-3619., (2011)

Nakagawa, H., Wakabayashi-Nakao, K., Tamura, A., Koshiba, S., Toyoda, Y., and Ishikawa, T., Disruption of N-linked glycosylation enhances ubiquitin-mediated proteasomal degradation of human ATP-binding cassette transporter ABCG2. FEBS J., 276, 7237-7252., (2009)

Nakagawa, H., Tamura, A., Wakabayashi, K., Hoshijima, K., Komada, M., Yoshida, T., Kometani, S., Matsubara, T., Mikuriya, K., and Ishikawa, T., Evidence for ubiquitin-mediated proteasomal degradation of non-synonymous SNP Variants. Biochemical J., 411, 623-631., (2008)

Nakagawa, H., Hasumi, K., Takami, M., Aida-Hyugaji, S., Woo, JT., Nagai, K., Ishikawa, T., and Wachi, M., Identification of two biologically-crucial hydroxyl groups of (–)-epigallocatechin gallate in osteoclast culture. Biochem. Pharmacol., 73, 34-43., (2007)

Nakagawa, H., Hasumi, K., Woo, JT., Nagai, K., and Wachi, M., Generation of hydrogen peroxide primarily contributes to the induction of Fe(II)-dependent apoptosis in Jurkat cells by (–)-epigallocatechin gallate. Carcinogenesis, 25, 1567-1574., (2004)

Nakagawa, H., Takami, M., Udagawa, N., Sawae, Y., Suda, K., Sasaki, T., Takahashi, N., Wachi, M., Nagai, K., and Woo, JT., Destruxins, cyclodepsipeptides, block the formation of actin rings, and prominent clear zones and ruffled borders in osteoclasts. Bone, 33, 443-455., (2003)

Nakagawa, H., Wachi, M., Woo, JT., Kato, M., Kasai, S., Takahashi, F., Lee, IS., and Nagai, K., Fenton reaction is primarily involved in a mechanism of (-)-epigallocatechin-3-gallate to induce osteoclastic cell death. Biochem. Biophys. Res. Commun., 292, 94-101., (2002)

講演、シンポジウム、学会発表

Nakagawa, H., Tamura, A., Li, S., Aida-Hyugaji, S., Regasini LO, Bolzani Vda S, Hirose, S., Ishikawa, T., Fricker, G., and Efferth, T., The combination of isoprenyl and guanidium core structural units influences the affinity level of guanidine alkaloid for human ATP-Binding Cassette Transporter ABCB1. The FEBS-ABC2012 – 4th FEBS Special Meeting on ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases., (March, 2012. Innsbruck)

Nakagawa, H., Wakabayashi-Nakao, K., Tamura, A., Koshiba, S., Toyoda, Y., Furukawa, T., and Ishikawa, T., The impacts of posttranslational modifications and non-synonymous SNPs on the protein stability of human ABC transporter ABCG2 protein in culture cells. The FEBS-ABC2010 - 3rd FEBS Special Meeting on ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases., (March, 2010. Innsbruck)

受賞

Special ABC2010 Poster Recognition Award., The FEBS-ABC2010 - 3rd FEBS Special Meeting on ATP-Binding Cassette (ABC) Proteins: From Multidrug Resistance to Genetic Diseases., (March, 2010. Innsbruck)