中部大学

中部大学

教員情報

金丸 京子 KANAMARU Kyoko

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職名 准教授
所属 応用生物学部 応用生物化学科
大学院 応用生物学研究科 応用生物学専攻
最終学歴 名古屋大学大学院農学研究科修了
学位 博士(農学)(名古屋大学)
専門分野 応用微生物学
研究テーマ 糸状菌の環境応答、有用酵素の機能解析

学術論文、評論

Generation of mitochondrial reactive oxygen species through a histidine kinase, HysA in Aspergillus nidulans, Kanamaru K, Izuhara K, Kimura M, Kobayashi T, J Gen Appl Microbiol, in press, 2021.

Impact of nitrogen metabolism-associated culture pH changes on regulation of Fusarium trichothecene biosynthesis: revision of roles of polyamine agmatine and transcription factor AreA. Yuichi Nakajima, Manami Akasaka, Takuya Shiobara, Yoshiyuki Kitou, Kazuyuki Maeda, Kyoko Kanamaru, Shuichi Ohsato, Tetsuo Kobayashi, Takumi Nishiuchi, Makoto Kimura. Current Genetics, 2020.

Synthetic liquid media for the study of trichothecene biosynthesis regulation in Fusarium graminearum, Asuka Nakao, Yuichi Nakajima, Manami Akasaka, Yoshiyuki Kitou, Kazuyuki Maeda, Kyoko Kanamaru, Tetsuo Kobayashi, Makoto Kimura. JSM Mycotoxins 70(2) 57-59, 2020.

Substrate specificities of Fusarium biosynthetic enzymes explain the genetic basis of a mixed chemotype producing both deoxynivalenol and nivalenol-type trichothecenes. Kazuyuki Maeda, Yuya Tanaka, Momoko Matsuyama, Masayuki Sato, Kazuki Sadamatsu, Tamotsu Suzuki, Kosuke Matsui, Yuichi Nakajima, Takeshi Tokai, Kyoko Kanamaru, Shuichi Ohsato, Tetsuo Kobayashi, Makoto Fujimura, Takumi Nishiuchi, Naoko Takahashi-Ando, Makoto Kimura. International Journal of Food Microbiology 320 108532-108532, 2020.

CreA-independent carbon catabolite repression of cellulase genes by trimeric G-protein and protein kinase A in Aspergillus nidulans, Emi Kunitake, Yi Li, Ryota Uchida, Takehiro Nohara, Keisuke Asano, Asato Hattori, Tetsuya Kimura, Kyoko Kanamaru, Makoto Kimura, Tetsuo Kobayshi. Current Genetics 65(4) 941-952, 2019.

Identification of amino acids negatively affecting Fusarium trichothecene biosynthesis. Shiobara T, Nakajima Y, Maeda K, Akasaka M, Kitou Y, Kanamaru K, Ohsato S, Kobayashi T, Nishiuchi T, Kimura M. Antonie van Leeuwenhoek 112(3) 471-478, 2018.

Inhibition of Fusarium trichothecene biosynthesis by yeast extract components extractable with ethyl acetate. Tanaka Y, Nakajima Y, Maeda K, Matsuyama M, Kanamaru K, Kobayashi T, Ohsato S, Kimura M. International journal of food microbiology 289 24-29, 2018.

Identification and Characterization of Small Molecule Compounds That Modulate Trichothecene Production by Fusarium graminearum. Kazuyuki Maeda, Hinayo Ichikawa, Yuichi Nakajima, Takayuki Motoyama, Shuichi Ohsato, Kyoko Kanamaru, Tetsuo Kobayashi, Takumi Nishiuchi, Hiroyuki Osada, Makoto Kimura. ACS Chemical Biology 13(5) 1260-1269, 2018.

Comparison of the paralogous transcription factors AraR and XlnR in Aspergillus oryzae. Kana Ishikawa, Emi Kunitake, Tomomi Kawase, Motoki Atsumi, Yuji Noguchi, Shuhei Ishikawa, Masahiro Ogawa, Yasuji Koyama, Makoto Kimura, Kyoko Kanamaru, Masashi Kato, Tetsuo Kobayashi. Current Genetics 64(6) 1-16, 2018.

Increased metabolite production by deletion of an HDA1-type histone deacetylase in the phytopathogenic fungi, Magnaporthe oryzae (Pyricularia oryzae) and Fusarium asiaticum. K. Maeda, M. Izawa, Y. Nakajima, Q. Jin, T. Hirose, T. Nakamura, H. Koshino, K. Kanamaru, S. Ohsato, T. Kamakura, T. Kobayashi, M. Yoshida, M. Kimura. LETTERS IN APPLIED MICROBIOLOGY 65(5) 446-452, 2017.

L-Threonine and its analogue added to autoclaved solid medium suppress trichothecene production by Fusarium graminearum. Kazuyuki Maeda, Yuichi Nakajima, Yoshikazu Tanahashi, Yoshiyuki Kitou, Akihiro Miwa, Kyoko Kanamaru, Tetsuo Kobayashi, Takumi Nishiuchi, Makoto Kimura. ARCHIVES OF MICROBIOLOGY 199(6) 945-952, 2017.

Identification of a trichothecene production inhibitor by chemical array and library screening using trichodiene synthase as a target protein. Kazuyuki Maeda, Yuichi Nakajima, Takayuki Motoyama, Yasumitsu Kondoh, Tatsuro Kawamura, Kyoko Kanamaru, Shuichi Ohsato, Takumi Nishiuchi, Minoru Yoshida, Hiroyuki Osada, Tetsuo Kobayashi, Makoto Kimura. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 138 1-7, 2017.

Accumulation of an unusual trichothecene shunt metabolite in liquid culture of Fusarium graminearum with methionine as the sole nitrogen source. Yuichi Nakajima, Yuya Tanaka, Kosuke Matsui, Kazuyuki Maeda, Yoshiyuki Kitou, Kyoko Kanamaru, Shuichi Ohsato, Tetsuo Kobayashi, Naoko Takahashi-Ando, Makoto Kimura. JSM Mycotoxins 67(1) 7-9, 2017.

McmA-dependent and -independent regulatory systems governing expression of ClrB-regulated cellulase and hemicellulase genes in Aspergillus nidulans. Nuo Li, Emi Kunitake, Miki Aoyama, Masahiro Ogawa, Kyoko Kanamaru, Makoto Kimura, Yasuji Koyama, Tetsuo Kobayashi. MOLECULAR MICROBIOLOGY 102(5) 810-826 2016.

Oligosaccharides containing an α-(1→2) (glucosyl/xylosyl)-fructosyl linkage as inducer molecules of trichothecene biosynthesis for Fusarium graminearum. Nakajima Y, Maeda K, Jin Q, Takahashi-Ando N, Kanamaru K, Kobayashi T, Kimura M. International journal of food microbiology 238 215-221, 2016.

Hydroxylations of trichothecene rings in the biosynthesis of Fusarium trichothecenes: evolution of alternative pathways in the nivalenol chemotype. Kazuyuki Maeda, Akira Tanaka, Ryosuke Sugiura, Hiroyuki Koshino, Takeshi Tokai, Masayuki Sato, Yuichi Nakajima, Yoshikazu Tanahashi, Kyoko Kanamaru, Tetsuo Kobayashi, Takumi Nishiuchi, Makoto Fujimura, Naoko Takahashi-Ando, Makoto Kimura. ENVIRONMENTAL MICROBIOLOGY 18(11) 3798-3811, 2016.

Involvement of an SRF-MADS protein McmA in regulation of extracellular enzyme production and asexual/sexual development in Aspergillus nidulans. Nuo Li, Emi Kunitake, Yoshikazu Endo, Miki Aoyama, Kyoko Kanamaru, Makoto Kimura, Masashi Kato, Tetsuo Kobayashi. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 80(9) 1820-1828, 2016.

Regulation of genes encoding cellulolytic enzymes by Pal-PacC signaling in Aspergillus nidulans. Emi Kunitake, Daisuke Hagiwara, Kentaro Miyamoto, Kyoko Kanamaru, Makoto Kimura, Tetsuo Kobayashi. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 100(8) 3621-3635, 2016.

Re-examination of genetic and nutritional factors related to trichothecene biosynthesis in Fusarium graminearum. Yoshiyuki Kitou, Yuichi Nakajima, Kazuyuki Maeda, Qi Jin, Takumi Nishiuchi, Kyoko Kanamaru, Tetsuo Kobayashi, Makoto Kimura. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 80(2) 414-417, 2016.

Nuclear localization and relative stability of the zinc finger domain of TRI6 trichothecene regulator. Yuichi Nakajima, Kazuyuki Maeda, Shuichi Ohsato, Kyoko Kanamaru, Tetsuo Kobayashi, Makoto Kimura. Mycotoxins 66(1) 13, 2016.

Introduction of a leptomycin-sensitive mutation into Fusarium graminearum. Yuichi Nakajima, Kazuyuki Maeda, Shuichi Ohsato, Kyoko Kanamaru, Tetsuo Kobayashi, Makoto Kimura. JSM Mycotoxins 66(1) 9-11, 2016.

Nuclear localization and relative stability of the zinc finger domain of TRI6 trichothecene regulator. Yuichi Nakajima, Kazuyuki Maeda, Shuichi Ohsato, Kyoko Kanamaru, Tetsuo Kobayashi, Makoto Kimura. JSM Mycotoxins 66(1) 13-15, 2016.

Trichothecene production in axenic liquid culture of Fusarium graminearum using xylose as a carbon source. Yoshiyuki Kitou, Takahiro Kosaki, Kazuyuki Maeda, Yoshikazu Tanahashi, Yuichi Nakajima, Kyoko Kanamaru, Tetsuo Kobayashi, Makoto Kimura. JSM Mycotoxins 66(1) 17-19, 2016.

Spatial Abundance and Distribution of Potential Microbes and Functional Genes Associated with Anaerobic Mineralization of Pentachlorophenol in a Cylindrical Reactor. Zhi-Ling Li, Jun Nan, Cong Huang, Bin Liang, Wen-Zong Liu, Hao-Yi Cheng, Chunfang Zhang, Dongdong Zhang, Deyong Kong, Kyoko Kanamaru, Tetsuo Kobayashi, Ai-Jie Wang, Arata Katayama. SCIENTIFIC REPORTS 6 19015, 2016.

Characterization of the acivicin effects on trichothecene production by Fusarium graminearum species complex. Kazuyuki Maeda, Yuichi Nakajima, Yoshikazu Tanahashi, Takahiro Kosaki, Yoshiyuki Kitou, Kyoko Kanamaru, Tetsuo Kobayashi, Takumi Nishiuchi, Makoto Kimura. JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY 62(5) 272-276, 2016.

Production of reactive oxygen species in Aspergillus nidulans through the function of His-Asp phosphorelay signal transduction system. Kyoko Kanamaru, Saki Hayashi, Kensuke Kojima, Tetsuo Kobayashi. Mycotoxins 65(1) 49, 2015.

Effect of disrupting the trichothecene efflux pump encoded by FgTril2 in the nivalenol chemotype of Fusarium graminearum. Yuichi Nakajima, Norifumi Koseki, Ryosuke Sugiura, Naoki Tominaga, Kazuyuki Maeda, Takeshi Tokai, Masumi Izawa, Kyoko Kanamaru, Takashi Kamakura, Tetsuo Kobayashi, Takumi Nishiuchi, Minoru Yoshida, Makoto Kimura. JOURNAL OF GENERAL AND APPLIED MICROBIOLOGY 61(3) 93-96, 2015.

Effects of acivicin on growth, mycotoxin production and virulence of phytopathogenic fungi. K. Maeda, Y. Nakajima, T. Motoyama, Y. Kitou, T. Kosaki, T. Saito, T. Nishiuchi, K. Kanamaru, H. Osada, T. Kobayashi, M. Kimura. LETTERS IN APPLIED MICROBIOLOGY 59(4) 377-383, 2014.

Identification of the Augmin Complex in the Filamentous Fungus Aspergillus nidulans. Tomoya Edzuka, Lixy Yamada, Kyoko Kanamaru, Hitoshi Sawada, Gohta Goshima. PLOS ONE 9(7), 2014.

A set of heterologous promoters useful for investigating gene functions in Fusarium graminearum. Yuichi Nakajima, Takeshi Tokai, Kazuyuki Maeda, Akira Tanaka, Naoko Takahashi-Ando, Kyoko Kanamaru, Tetsuo Kobayashi, Makoto Kimura. JSM Mycotoxins 64(2) 147-152, 2014.

Control of reactive oxygen species (ROS) production through histidine kinases in Aspergillus nidulans under different growth conditions. Saki Hayashi, Megumi Yoshioka, Tetsuji Matsui, Kensuke Kojima, Masashi Kato, Kyoko Kanamaru, Tetsuo Kobayashi. FEBS OPEN BIO 4 90-95, 2014.

Regulation of cellulolytic genes by McmA, the SRF-MADS box protein in Aspergillus nidulans. Yohei Yamakawa, Yoshikazu Endo, Nuo Li, Makoto Yoshizawa, Miki Aoyama, Ayako Watanabe, Kyoko Kanamaru, Masashi Kato, Tetsuo Kobayashi. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 431(4) 777-782, 2013.

Lack of the Consensus Sequence Necessary for Tryptophan Prenylation in the ComX Pheromone Precursor. Fumitada Tsuji, Ayako Ishihara, Aya Nakagawa, Masahiro Okada, Shigeyuki Kitamura, Kyoko Kanamaru, Yuichi Masuda, Kazuma Murakami, Kazuhiro Irie, Youji Sakagami. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 76(8) 1492-1496, 2012.

ASYMMETRIC-LEAVES2 and an ortholog of eukaryotic NudC domain proteins repress expression of AUXIN-RESPONSE-FACTOR and class 1 KNOX homeobox genes for development of flat symmetric leaves in Arabidopsis. Nanako Ishibashi, Kyoko Kanamaru, Yoshihisa Ueno, Shoko Kojima, Tetsuo Kobayashi, Chiyoko Machida, Yasunori Machida. BIOLOGY OPEN 1(3) 197-207, 2012.

Geranyl modification on the tryptophan residue of ComX(RO-E-2) pheromone by a cell-free system. Fumitada Tsuji, Ayako Ishihara, Keiko Kurata, Aya Nakagawa, Masahiro Okada, Shigeyuki Kitamura, Kyoko Kanamaru, Yuichi Masuda, Kazuma Murakami, Kazuhiro Irie, Youji Sakagami. FEBS LETTERS 586(2) 174-179, 2012.

Xylose Triggers Reversible Phosphorylation of XlnR, the Fungal Transcriptional Activator of Xylanolytic and Cellulolytic Genes in Aspergillus oryzae. Yuji Noguchi, Hisaki Tanaka, Kyoko Kanamaru, Masashi Kato, Tetsuo Kobayashi. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 75(5) 953-959, 2011.

Roles of the His-Asp Phosphorelay Signal Transduction System in Controlling Cell Growth and Development in Aspergillus nidulans. Kyoko Kanamaru. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 75(1) 1-6, 2011.

Genes regulated by AoXlnR, the xylanolytic and cellulolytic transcriptional regulator, in Aspergillus oryzae. Yuji Noguchi, Motoaki Sano, Kyoko Kanamaru, Taro Ko, Michio Takeuchi, Masashi Kato, Tetsuo Kobayashi. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 85(1) 141-154 2009.

GFP-Tagged expression analysis revealed that some histidine kinases of Aspergillus nidulans show temporally and spatially different expression during the life cycle. Asako Suzuki, Kyoko Kanamaru, Nobuhiro Azuma, Masashi Kato, Tetsuo Kobayashi. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 72(2) 428-434, 2008.

In vitro analysis of His-Asp phosphorelays in Aspergillus nidulans: The first direct biochemical evidence for the existence of His-Asp phosphotransfer systems in filamentous fungi. Nobuhiro Azuma, Kyoko Kanamaru, Akinori Matsushika, Takafumi Yamashino, Takeshi Mizuno, Masashi Kato, Tetsuo Kobayashi. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 71(10) 2493-2502, 2007.

Complete reconstitution of an ATP-binding cassette transporter LolCDE complex from separately isolated subunits. Kyoko Kanamaru, Naohiro Taniguchi, Shigehiko Miyamoto, Shin-ichiro Narita, Hajime Tokuda. FEBS JOURNAL 274(12) 3034-3043, 2007.

The SskA and SrrA response regulators are implicated in oxidative stress responses of hyphae and asexual spores in the phosphorelay signaling network of Aspergillus nidulans. Daisuke Hagiwara, Yoshihiro Asano, Junichiro Marui, Kentaro Furukawa, Kyoko Kanamaru, Masashi Kato, Keietsu Abe, Tetsuo Kobayashi, Takafumi Yamashino, Takeshi Mizuno. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 71(4) 1003-1014, 2007.

Characterization of the NikA histidine kinase implicated in the phosphorelay signal transduction of Aspergillus nidulans, with special reference to fungicide responses. Daisuke Hagiwara, Yoshihiro Matsubayashi, Junichiro Marui, Kentaro Furukawa, Takafumi Yamashino, Kyoko Kanamaru, Masashi Kato, Keietsu Abe, Tetsuo Kobayashi, Takeshi Mizuno. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 71(3) 844-847, 2007.

A novel ligand bound ABC transporter, LolCDE, provides insights into the molecular mechanisms underlying membrane detachment of bacterial lipoproteins. Yasuko Ito, Kyoko Kanamaru, Naohiro Taniguchi, Shigehiko Miyamoto, Hajime Tokuda. MOLECULAR MICROBIOLOGY 62(4) 1064-1075, 2006.

A mutation in the membrane subunit of an ABC transporter LolCDE complex causing outer membrane localization of lipoproteins against their inner membrane-specific signals. S Narita, K Kanamaru, S Matsuyama, H Tokuda. MOLECULAR MICROBIOLOGY 49(1) 167-177, 2003.

Overexpression of the PepF oligopeptidase inhibits sporulation initiation in Bacillus subtilis. K Kanamaru, S Stephenson, M Perego. JOURNAL OF BACTERIOLOGY 184(1) 43-50, 2002.

Dissection of the functional and structural domains of phosphorelay histidine kinase a of Bacillus subtilis. L Wang, C Fabret, K Kanamaru, K Stephenson, Dartois, V, M Perego, JA Hoch. JOURNAL OF BACTERIOLOGY 183(9) 2795-2802, 2001.

SdiA, an Escherichia coli homologue of quorum-sensing regulators, controls the expression of virulence factors in enterohaemorrhagic Escherichia coli O157 : H7. K Kanamaru, K Kanamaru, Tatsuno, I, T Tobe, C Sasakawa. MOLECULAR MICROBIOLOGY 38(4) 805-816, 2000.

Regulation of virulence factors of enterohemorrhagic Escherichia coli O157 : H7 by self-produced extracellular factors. K Kanamaru, K Kanamaru, Tatsuno, I, T Tobe, C Sasakawa. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 64(11) 2508-2511, 2000.

Isolation and characterization of mini-Tn5Km2 insertion mutants of enterohemorrhagic Escherichia coli O157 : H7 deficient in adherence to caco-2 cells. Tatsuno, I, H Kimura, A Okutani, K Kanamaru, H Abe, S Nagai, K Makino, H Shinagawa, M Yoshida, K Sato, J Nakamoto, T Tobe, C Sasakawa. INFECTION AND IMMUNITY 68(10) 5943-5952, 2000.

A novel member of the cspA family of genes that is induced by cold shock in Escherichia coli. K Nakashima, K Kanamaru, T Mizuno, K Horikoshi. JOURNAL OF BACTERIOLOGY 178(10) 2994-2997, 1996.

High pressure represses expression of the malB operon in Escherichia coli. T Sato, Y Nakamura, KK Nakashima, C Kato, K Horikoshi. FEMS MICROBIOLOGY LETTERS 135(1) 111-116, 1996.

Osmoregulation of fission yeast: Cloning of two distinct genes encoding glycerol-3-phosphate dehydrogenase, one of which is responsible for osmotolerance for growth. R Ohmiya, H Yamada, K Nakashima, H Aiba, T Mizuno. MOLECULAR MICROBIOLOGY 18(5) 963-973, 1995.

Effect of hydrostatic-pressure on the synthesis of outer-membrane proteins in Escherichia-coli. K Nakashima, K Horikoshi, T Mizuno. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 59(1) 130-132, 1995.

Signal-sensing mechanisms of the putative osmosensor kdpd in Escherichia-coli. A Sugiura, K Hirokawa, K Nakashima, T Mizuno. MOLECULAR MICROBIOLOGY 14(5) 929-938, 1994.

Functional reconstitution of the putative Escherichia-coli osmosensor, Kdpd, into liposomes. K Nakashima, A Sugiura, T Mizuno. JOURNAL OF BIOCHEMISTRY 114(4) 615-621, 1993.

Sequence-directed DNA curvature in activator-binding sequence in the Escherichia-coli kdpABC promoter. A Sugiura, K Nakashima, T Mizuno. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY 57(2) 356-357, 1993.

Signal transduction between the 2 regulatory components involved in the regulation of the kdpABC operon in Escherichia-coli - phosphorylation-dependent functioning of the positive regulator, KdpE. K Nakashima, A Sugiura, K Kanamaru, T Mizuno. MOLECULAR MICROBIOLOGY 7(1) 109-116, 1993.

Phosphotransfer signal transduction between 2 regulatory factors involved in the osmoregulated kdp operon in Escherichia-coli. K Nakashima, A Sugiura, H Momoi, T Mizuno. MOLECULAR MICROBIOLOGY 6(13) 1777-1784, 1992.

Clarification of the structural and functional features of the osmoregulated kdp operon of Escherichia-coli. A Sugiura, K Nakashima, K Tanaka, T Mizuno. MOLECULAR MICROBIOLOGY 6(13) 1769-1776, 1992.

Osmoregulatory expression of the porin genes in Escherichia-coli - evidence for signal titration in the signal transduction through EnvZ-OmpR phosphotransfer. K Nakashima, K Kanamaru, H Aiba, T Mizuno. FEMS MICROBIOLOGY LETTERS 82(1) 43-47, 1991.

Signal transduction and osmoregulation in Escherichia-coli - a novel type of mutation in the phosphorylation domain of the activator protein, OmpR, results in a defect in its phosphorylation-dependent DNA-binding. K Nakashima, K Kanamaru, H Aiba, T Mizuno. JOURNAL OF BIOLOGICAL CHEMISTRY 266(17) 10775-10780, 1991.

総説・著書・その他刊行物

加藤雅士, 金丸京子, 小林哲夫:糸状菌Aspergillus nidulansのHis-Aspリン酸リレーネットワークの全体像: 化学と生物, 47, 718-724 (2009) 

金丸京子*, 松山伸一, 徳田 元:リポ蛋白質の選択的局在化機構;蛋白質核酸酵素49, 961-964 (2004) 

その他

特許

カビの胞子着生率に影響するキナーゼ遺伝子の利用方法, 小林哲夫, 加藤雅士, 金丸京子 (特願2008-051260, 2008年)

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