市原 正智 ICHIHARA Masatoshi


職名 教授
所属 生命健康科学部 生命医科学科
大学院 生命健康科学研究科 生命医科学専攻
最終学歴 名古屋大学大学院医学研究科
学位 医学博士
資格 医師
所属学会・役職 日本内科学会
専門分野 病理学、血液学、分子生物学
研究テーマ 分子状水素の生体作用の解明、疾患モデル動物の責任遺伝子解析


遺伝子医療-基礎から応用へ, "Ret遺伝子とその異常"(共著), 名古屋大学出版会, 2000


Nishiwaki, H., Ito, M., Negishi, S., Sobue, S., Ichihara, M, Ohno, K. Molecular hydrogen upregulates heat shock response and collagen biosynthesis, and downregulates cell cycles: meta-analyses of gene expression profiles. Free Radic Res.52, 434-445 (2018)

Matsuoka, H., Miyata, S., Okumura, N., Watanabe, T., Hashimoto, K., Nagahara, M., Kato, K., Sobue, S., Takeda, K., Ichihara, M., Iwamoto, T, Noda, A. Hydrogen gas improves left ventricular hypertrophy in Dahl rat of salt-sensitive hypertension. Clin Exp Hypertens, 1-5 (2018)

Inoue, C., Sobue, S., Aoyama, Y., Mizutani, N., Kawamoto, Y., Nishizawa, Y., Ichihara, M., Abe, A., Hayakawa, F., Suzuki, M., Nozawa, Y, Murate, T. BCL2 inhibitor ABT-199 and JNK inhibitor SP600125 exhibit synergistic cytotoxicity against imatinib-resistant Ph+ ALL cells. Biochem Biophys Rep.15, 69-75 (2018)

Sobue, S., Inoue, C., Hori, F., Qiao, S., Murate, T, Ichihara, M. Molecular hydrogen modulates gene expression via histone modification and induces the mitochondrial unfolded protein response. Biochem Biophys Res Commun.493, 318-324 (2017)

Imoto, N., Harunori, N., Furukawa, K., Tange, N., Murase, A., Hayakawa, M., Ichihara, M., Iwata, Y, Kosugi, H. GM-CSF Autoantibody-positive Pulmonary Alveolar Proteinosis with Simultaneous Myeloproliferative Neoplasm. Intern Med.56, 435-439 (2017)

Aoyama, Y., Sobue, S., Mizutani, N., Inoue, C., Kawamoto, Y., Nishizawa, Y., Ichihara, M., Kyogashima, M., Suzuki, M., Nozawa, Y, Murate, T. Modulation of the sphingolipid rheostat is involved in paclitaxel resistance of the human prostate cancer cell line PC3-PR. Biochem Biophys Res Commun.486, 551-557 (2017)

Sobue, S., Sakata, K., Sekijima, Y., Qiao, S., Murate, T, Ichihara, M. Characterization of gene expression profiling of mouse tissues obtained during the postmortem interval. Exp Mol Pathol.100, 482-492 (2016)

Sobue, S., Mizutani, N., Aoyama, Y., Kawamoto, Y., Suzuki, M., Nozawa, Y., Ichihara, M, Murate, T. Mechanism of paclitaxel resistance in a human prostate cancer cell line, PC3-PR, and its sensitization by cabazitaxel. Biochem Biophys Res Commun.479, 808-813 (2016)

Mizutani, N., Omori, Y., Kawamoto, Y., Sobue, S., Ichihara, M., Suzuki, M., Kyogashima, M., Nakamura, M., Tamiya-Koizumi, K., Nozawa, Y, Murate, T. Resveratrol-induced transcriptional up-regulation of ASMase (SMPD1) of human leukemia and cancer cells. Biochem Biophys Res Commun.470, 851-856 (2016)

Sobue, S., Yamai, K., Ito, M., Ohno, K., Ito, M., Iwamoto, T., Qiao, S., Ohkuwa, T, Ichihara, M. Simultaneous oral and inhalational intake of molecular hydrogen additively suppresses signaling pathways in rodents. Mol Cell Biochem.403, 231-241 (2015)

Ichihara, M., Sobue, S., Ito, M., Ito, M., Hirayama, M, Ohno, K. Beneficial biological effects and the underlying mechanisms of molecular hydrogen - comprehensive review of 321 original articles. Med Gas Res.5, 12 (2015)

Sakakura, H., Murakumo, Y., Mii, S., Hagiwara, S., Kato, T., Asai, M., Hoshino, A., Yamamoto, N., Sobue, S., Ichihara, M., Ueda, M, Takahashi, M. Detection of a soluble form of CD109 in serum of CD109 transgenic and tumor xenografted mice. PLoS One.9, e83385 (2014)

Qiao, S., Fan, K., Iwashita, T., Ichihara, M., Yoshino, M, Takahashi, M. The involvement of reactive oxygen species derived from NADPH oxidase-1 activation on the constitutive tyrosine auto-phosphorylation of RET proteins. Free Radic Res.48, 427-434 (2014)

Miyata, M., Ichihara, M., Tajima, O., Sobue, S., Kambe, M., Sugiura, K., Furukawa, K, Furukawa, K. UVB-irradiated keratinocytes induce melanoma-associated ganglioside GD3 synthase gene in melanocytes via secretion of tumor necrosis factor alpha and interleukin 6. Biochem Biophys Res Commun.445, 504-510 (2014)

Mizutani, N., Kobayashi, M., Sobue, S., Ichihara, M., Ito, H., Tanaka, K., Iwaki, S., Fujii, S., Ito, Y., Tamiya-Koizumi, K., Takagi, A., Kojima, T., Naoe, T., Suzuki, M., Nakamura, M., Banno, Y., Nozawa, Y, Murate, T. Sphingosine kinase 1 expression is downregulated during differentiation of Friend cells due to decreased c-MYB. Biochim Biophys Acta.1833, 1006-1016 (2013)

Takaoka, Y., Shimizu, Y., Hasegawa, H., Ouchi, Y., Qiao, S., Nagahara, M., Ichihara, M., Lee, JD., Adachi, K., Hamaguchi, M, Iwamoto, T. Forced expression of miR-143 represses ERK5/c-Myc and p68/p72 signaling in concert with miR-145 in gut tumors of Apc(Min) mice. PLoS One.7, e42137 (2012)

Qiao, S., Murakami, K., Zhao, Q., Wang, B., Seo, H., Yamashita, H., Li, X., Iwamoto, T., Ichihara, M, Yoshino, M. Mimosine-induced apoptosis in C6 glioma cells requires the release of mitochondria-derived reactive oxygen species and p38, JNK activation. Neurochem Res.37, 417-427 (2012)

Ohno, K., Ito, M., Ichihara, M, Ito, M. Molecular hydrogen as an emerging therapeutic medical gas for neurodegenerative and other diseases. Oxid Med Cell Longev.2012, 353152 (2012)

Minami, M., Sobue, S., Ichihara, M, Hasegawa, T. Analysis of the pathological lesions of the lung in a mouse model of cutaneous infection with Streptococcus pyogenes. Pathol Int.62, 99-104 (2012)

Mii, S., Murakumo, Y., Asai, N., Jijiwa, M., Hagiwara, S., Kato, T., Asai, M., Enomoto, A., Ushida, K., Sobue, S., Ichihara, M, Takahashi, M. Epidermal hyperplasia and appendage abnormalities in mice lacking CD109. Am J Pathol.181, 1180-1189 (2012)

Ito, M., Hirayama, M., Yamai, K., Goto, S., Ito, M., Ichihara, M, Ohno, K. Drinking hydrogen water and intermittent hydrogen gas exposure, but not lactulose or continuous hydrogen gas exposure, prevent 6-hydorxydopamine-induced Parkinson's disease in rats. Med Gas Res.2, 15 (2012)

Ito, H., Tanaka, K., Hagiwara, K., Kobayashi, M., Hoshikawa, A., Mizutani, N., Takagi, A., Kojima, T., Sobue, S., Ichihara, M., Suzuki, M., Tamiya-Koizumi, K., Nakamura, M., Banno, Y., Nozawa, Y, Murate, T. Transcriptional regulation of neutral sphingomyelinase 2 in all-trans retinoic acid-treated human breast cancer cell line, MCF-7. J Biochem.151, 599-610 (2012)

Murakami, M., Ito, H., Hagiwara, K., Kobayashi, M., Hoshikawa, A., Takagi, A., Kojima, T., Tamiya-Koizumi, K., Sobue, S., Ichihara, M., Suzuki, M., Banno, Y., Nozawa, Y, Murate, T. Sphingosine kinase 1/S1P pathway involvement in the GDNF-induced GAP43 transcription. J Cell Biochem.112, 3449-3458 (2011)

Itoh, T., Hamada, N., Terazawa, R., Ito, M., Ohno, K., Ichihara, M., Nozawa, Y, Ito, M. Molecular hydrogen inhibits lipopolysaccharide/interferon gamma-induced nitric oxide production through modulation of signal transduction in macrophages. Biochem Biophys Res Commun.411, 143-149 (2011)

Ito, M., Ibi, T., Sahashi, K., Ichihara, M., Ito, M, Ohno, K. Open-label trial and randomized, double-blind, placebo-controlled, crossover trial of hydrogen-enriched water for mitochondrial and inflammatory myopathies. Med Gas Res.1, 24 (2011)

Murakami, M., Ito, H., Hagiwara, K., Yoshida, K., Sobue, S., Ichihara, M., Takagi, A., Kojima, T., Tanaka, K., Tamiya-Koizumi, K., Kyogashima, M., Suzuki, M., Banno, Y., Nozawa, Y, Murate, T. ATRA inhibits ceramide kinase transcription in a human neuroblastoma cell line, SH-SY5Y cells: the role of COUP-TFI. J Neurochem.112, 511-520 (2010)

Qiao, S., Iwashita, T., Ichihara, M., Murakumo, Y., Yamaguchi, A., Isogai, M., Sakata, K, Takahashi, M. Increased expression of glial cell line-derived neurotrophic factor and neurturin in a case of colon adenocarcinoma associated with diffuse ganglioneuromatosis. Clin Neuropathol.28, 105-112 (2009)

Itoh, T., Fujita, Y., Ito, M., Masuda, A., Ohno, K., Ichihara, M., Kojima, T., Nozawa, Y, Ito, M. Molecular hydrogen suppresses FcepsilonRI-mediated signal transduction and prevents degranulation of mast cells. Biochem Biophys Res Commun.389, 651-656 (2009)

Fu, Y., Ito, M., Fujita, Y., Ito, M., Ichihara, M., Masuda, A., Suzuki, Y., Maesawa, S., Kajita, Y., Hirayama, M., Ohsawa, I., Ohta, S, Ohno, K. Molecular hydrogen is protective against 6-hydroxydopamine-induced nigrostriatal degeneration in a rat model of Parkinson's disease. Neurosci Lett.453, 81-85 (2009)

Suzuki, C., Murakumo, Y., Kawase, Y., Sato, T., Morinaga, T., Fukuda, N., Enomoto, A., Ichihara, M, Takahashi, M. A novel GDNF-inducible gene, BMZF3, encodes a transcriptional repressor associated with KAP-1. Biochem Biophys Res Commun.366, 226-232 (2008)

Hasegawa, T., Enomoto, A., Kato, T., Kawai, K., Miyamoto, R., Jijiwa, M., Ichihara, M., Ishida, M., Asai, N., Murakumo, Y., Ohara, K., Niwa, Y., Goto, H, Takahashi, M. Roles of induced expression of MAPK phosphatase-2 in tumor development in RET-MEN2A transgenic mice. Oncogene.27, 5684-5695 (2008)

Murakami, M., Ichihara, M., Sobue, S., Kikuchi, R., Ito, H., Kimura, A., Iwasaki, T., Takagi, A., Kojima, T., Takahashi, M., Suzuki, M., Banno, Y., Nozawa, Y, Murate, T. RET signaling-induced SPHK1 gene expression plays a role in both GDNF-induced differentiation and MEN2-type oncogenesis. J Neurochem.102, 1585-1594 (2007)

Ishida, M., Ichihara, M., Mii, S., Jijiwa, M., Asai, N., Enomoto, A., Kato, T., Majima, A., Ping, J., Murakumo, Y, Takahashi, M. Sprouty2 regulates growth and differentiation of human neuroblastoma cells through RET tyrosine kinase. Cancer Sci.98, 815-821 (2007)

Ichihara, M., Murakumo, Y., Masuda, A., Matsuura, T., Asai, N., Jijiwa, M., Ishida, M., Shinmi, J., Yatsuya, H., Qiao, S., Takahashi, M, Ohno, K. Thermodynamic instability of siRNA duplex is a prerequisite for dependable prediction of siRNA activities. Nucleic Acids Res.35, e123 (2007)

Uchida, M., Enomoto, A., Fukuda, T., Kurokawa, K., Maeda, K., Kodama, Y., Asai, N., Hasegawa, T., Shimono, Y., Jijiwa, M., Ichihara, M., Murakumo, Y, Takahashi, M. Dok-4 regulates GDNF-dependent neurite outgrowth through downstream activation of Rap1 and mitogen-activated protein kinase. J Cell Sci.119, 3067-3077 (2006)

Murakumo, Y., Mizutani, S., Yamaguchi, M., Ichihara, M, Takahashi, M. Analyses of ultraviolet-induced focus formation of hREV1 protein. Genes Cells.11, 193-205 (2006)

Murakumo, Y., Jijiwa, M., Asai, N., Ichihara, M, Takahashi, M. RET and neuroendocrine tumors. Pituitary.9, 179-192 (2006)

Morinaga, T., Enomoto, A., Shimono, Y., Hirose, F., Fukuda, N., Dambara, A., Jijiwa, M., Kawai, K., Hashimoto, K., Ichihara, M., Asai, N., Murakumo, Y., Matsuo, S, Takahashi, M. GDNF-inducible zinc finger protein 1 is a sequence-specific transcriptional repressor that binds to the HOXA10 gene regulatory region. Nucleic Acids Res.33, 4191-4201 (2005)

Jin, Y., Murakumo, Y., Ueno, K., Hashimoto, M., Watanabe, T., Shimoyama, Y., Ichihara, M, Takahashi, M. Identification of a mouse cytoskeleton-associated protein, CKAP2, with microtubule-stabilizing properties. Cancer Sci.95, 815-821 (2004)

Jijiwa, M., Fukuda, T., Kawai, K., Nakamura, A., Kurokawa, K., Murakumo, Y., Ichihara, M, Takahashi, M. A targeting mutation of tyrosine 1062 in Ret causes a marked decrease of enteric neurons and renal hypoplasia. Mol Cell Biol.24, 8026-8036 (2004)

Ichihara, M., Murakumo, Y, Takahashi, M. RET and neuroendocrine tumors. Cancer Lett.204, 197-211 (2004)

Hashimoto, M., Ichihara, M., Watanabe, T., Kawai, K., Koshikawa, K., Yuasa, N., Takahashi, T., Yatabe, Y., Murakumo, Y., Zhang, JM., Nimura, Y, Takahashi, M. Expression of CD109 in human cancer. Oncogene.23, 3716-3720 (2004)

Shimoyama, Y., Morikawa, Y., Ichihara, M., Kodama, Y., Fukuda, N., Hayashi, H., Morinaga, T., Iwashita, T., Murakumo, Y, Takahashi, M. Identification of human SEP1 as a glial cell line-derived neurotrophic factor-inducible protein and its expression in the nervous system. Neuroscience.121, 899-906 (2003)

Kawai, K., Jijiwa, M., Shimono, Y., Kurokawa, K., Murakumo, Y., Ichihara, M, Takahashi, M. Establishment and characterization of mouse mammary carcinoma cell lines expressing RET with a multiple endocrine neoplasia 2A mutation. Cancer Sci.94, 992-997 (2003)

Fukuda, N., Ichihara, M., Morinaga, T., Kawai, K., Hayashi, H., Murakumo, Y., Matsuo, S, Takahashi, M. Identification of a novel glial cell line-derived neurotrophic factor-inducible gene required for renal branching morphogenesis. J Biol Chem.278, 50386-50392 (2003)

Watanabe, T., Ichihara, M., Hashimoto, M., Shimono, K., Shimoyama, Y., Nagasaka, T., Murakumo, Y., Murakami, H., Sugiura, H., Iwata, H., Ishiguro, N, Takahashi, M. Characterization of gene expression induced by RET with MEN2A or MEN2B mutation. Am J Pathol.161, 249-256 (2002)

Iwashita, T., Kurokawa, K., Qiao, S., Murakami, H., Asai, N., Kawai, K., Hashimoto, M., Watanabe, T., Ichihara, M, Takahashi, M. Functional analysis of RET with Hirschsprung mutations affecting its kinase domain. Gastroenterology.121, 24-33 (2001)

Kudo, K., Nagai, H., Numata, S., Ichihara, M., Kinoshita, T., Horibe, K., Kato, K., Matsuyama, T., Kodera, Y, Kojima, S. Absence of mutations in the granulocyte colony-stimulating factor (G-CSF) receptor gene in patients with myelodysplastic syndrome/acute myeloblastic leukaemia occurring after treatment of aplastic anaemia with G-CSF. Br J Haematol.111, 656-658 (2000)

Hayashi, H., Ichihara, M., Iwashita, T., Murakami, H., Shimono, Y., Kawai, K., Kurokawa, K., Murakumo, Y., Imai, T., Funahashi, H., Nakao, A, Takahashi, M. Characterization of intracellular signals via tyrosine 1062 in RET activated by glial cell line-derived neurotrophic factor. Oncogene.19, 4469-4475 (2000)

Nakayama, S., Iida, K., Tsuzuki, T., Iwashita, T., Murakami, H., Asai, N., Iwata, Y., Ichihara, M., Ito, S., Kawai, K., Asai, M., Kurokawa, K, Takahashi, M. Implication of expression of GDNF/Ret signalling components in differentiation of bone marrow haemopoietic cells. Br J Haematol.105, 50-57 (1999)

Murate, T., Yamashita, K., Isogai, C., Suzuki, H., Ichihara, M., Hatano, S., Nakahara, Y., Kinoshita, T., Nagasaka, T., Yoshida, S., Komatsu, N., Miura, Y., Hotta, T., Fujimoto, N., Saito, H, Hayakawa, T. The production of tissue inhibitors of metalloproteinases (TIMPs) in megakaryopoiesis: possible role of platelet- and megakaryocyte-derived TIMPs in bone marrow fibrosis. Br J Haematol.99, 181-189 (1997)

Ichihara, M., Hara, T., Kim, H., Murate, T, Miyajima, A. Oncostatin M and leukemia inhibitory factor do not use the same functional receptor in mice. Blood.90, 165-173 (1997)

Hara, T., Ichihara, M., Yoshimura, A, Miyajima, A. Cloning and biological activity of murine oncostatin M. Leukemia.11 Suppl 3, 449-450 (1997)

Yoshimura, A., Ichihara, M., Kinjyo, I., Moriyama, M., Copeland, NG., Gilbert, DJ., Jenkins, NA., Hara, T, Miyajima, A. Mouse oncostatin M: an immediate early gene induced by multiple cytokines through the JAK-STAT5 pathway. EMBO J.15, 1055-1063 (1996)

O'Farrell, AM., Ichihara, M., Mui, AL, Miyajima, A. Signaling pathways activated in a unique mast cell line where interleukin-3 supports survival and stem cell factor is required for a proliferative response. Blood.87, 3655-3668 (1996)

Takagi, M., Hara, T., Ichihara, M., Takatsu, K, Miyajima, A. Multi-colony stimulating activity of interleukin 5 (IL-5) on hematopoietic progenitors from transgenic mice that express IL-5 receptor alpha subunit constitutively. J Exp Med.181, 889-899 (1995)

Ichihara, M., Iwamoto, T., Isobe, K., Takahashi, M., Nakayama, A., Pu, M., Dai, Y., Parashar, A., Ohkus, K., Kato, M, et al. Oncogene-linked in situ immunotherapy of pre-B lymphoma arising in E mu/ret transgenic mice. Br J Cancer.71, 808-813 (1995)

Ichihara, M., Hara, T., Takagi, M., Cho, LC., Gorman, DM, Miyajima, A. Impaired interleukin-3 (IL-3) response of the A/J mouse is caused by a branch point deletion in the IL-3 receptor alpha subunit gene. EMBO J.14, 939-950 (1995)

Hara, T., Ichihara, M., Takagi, M, Miyajima, A. Interleukin-3 (IL-3) poor-responsive inbred mouse strains carry the identical deletion of a branch point in the IL-3 receptor alpha subunit gene. Blood.85, 2331-2336 (1995)

Ichihara, M., Hotta, T., Asano, H., Inoue, C., Murate, T., Kobayashi, M, Saito, H. Effects of stem cell factor (SCF) on human marrow neutrophil, neutrophil/macrophage mixed, macrophage and eosinophil progenitor cell growth. Int J Hematol.59, 81-89 (1994)

Asano, H., Ohashi, H., Ichihara, M., Kinoshita, T., Murate, T., Kobayashi, M., Saito, H, Hotta, T. Evidence for nonclonal hematopoietic progenitor cell populations in bone marrow of patients with myelodysplastic syndromes. Blood.84, 588-594 (1994)

Asano, H., Hotta, T., Ichihara, M., Murate, T., Kobayashi, M, Saito, H. Growth analysis of marrow CD34-positive hematopoietic progenitor cells in patients with myelodysplastic syndromes. Leukemia.8, 833-838 (1994)

Hotta, T., Goto, S., Tsushita, K., Kagami, Y., Ohashi, H., Ichikawa, A., Ichihara, M., Takagi, N., Murate, T., Yamao, H, et al. Cytogenetic and clonal culture evaluation after response to low dose Ara-C in myelodysplastic syndromes. Leukemia.5, 962-966 (1991)

Takeshita, A., Hirabayashi, N., Ichihara, M, Miwa, Y. Treatment of chronic granulocytic leukemia in the accelerated phase by transfusion of autologous buffy-coat cells--a case report. Nihon Ketsueki Gakkai Zasshi.53, 51-56 (1990)